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interstellar medium and dusty star formation in high-redshift galaxies, including a detailed case study of a z~4 submillimeter galaxy. I will then discuss our current efforts with the Atacama Large Millimeter Array (ALMA) to expand the sample size beyond one. I will end with a discussion of future prospects for using such long-wavelength studies to understand the nature of high-redshift star formation and, consequently, how today’s galaxy population developed through cosmic time.